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Various issues can cause a bump to form in, on, or around the anus. Most of these causes are treatable, and some are more serious than others. A person should not ignore persistent anal bleeding or discomfort.


You don't have to have sex to get an STD. Skin-to-skin contact is enough to spread HPV, the virus family that causes genital warts. Some types cause warts and are usually harmless, but others may lead to cervical or anal cancer. Vaccines can protect against some of the most dangerous types.


"Crabs" is the common term for lice that set up shop in pubic hair. The term comes from the shape of the tiny parasites, which look very different from head or body lice. The creatures crawl from one person to another during close contact. Pubic lice can be killed with over-the-counter lotions.


Scabies is an itchy infestation caused by a tiny mite that burrows into human skin to lay eggs. It is not always an STD, as it can spread through any skin-to-skin contact. But among young adults, the mites are often acquired during sex. Scabies is treated with prescription creams.


Symptoms: Open sores on the genitals or anus, headache, fever, fatigue, and swollen lymph glands in the groin (seen here). If acquired through anal sex, LGV may cause rectal bleeding or discharge.


Some anal cancers cause no symptoms at all. But symptoms of anal cancer can include changes in your poop, bleeding, itching, and pain or a lump at the anal opening. The doctor will ask you questions about your health and do a physical exam. The doctor will also look at your anus and may put a gloved finger inside to check for lumps. (This is called a rectal exam. The rectum is the part of the large intestine that connects to the anus.)


Endoscopy: For this test, a flexible (not firm) tube with a tiny video camera and light on the end (called an endoscope) is put into the anus, rectum, and sometimes the entire colon to look inside. This flexible tube is much longer than the anoscope and might be used to make sure that an anal cancer symptom, such as bleeding, is not coming from another area like the rectum or colon. It can also be used to take out cells (a biopsy) from inside these areas. You will be given medicine to stay drowsy or asleep during this test.


In a biopsy, the doctor takes out a small piece of tissue where the cancer seems to be. The tissue is checked for cancer cells. A biopsy is the only way to know for sure if you have cancer. For anal cancer, a biopsy is most often done during an endoscopy. If the tumor is very small and is only on the lining of the anus, the doctor may be able to take out all of the tumor during the biopsy.


If you have anal cancer, the doctor will want to find out how far it has spread. This is called staging. Your doctor will want to find out the stage of your cancer to help decide what type of treatment is best for you.


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A rectal ulcer is a painful sore that develops inside the rectum. The rectum is a tube connecting the colon (lower intestine) to the anal opening (anus). Stool passes through the rectum and anus when it leaves the body.


After making a few small incisions near your belly button, doctors insert a laparoscope (a thin instrument with a camera) into your abdomen. Your doctor uses tiny tools to move your rectum into the proper position.


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A skin tag is a tiny, benign, outpouching of skin that is typically connected to the underlying skin by a thin stalk. Skin tags look like tiny bits of "hanging" skin and typically occur in sites where clothing rubs against the skin or where there is skin-to-skin friction, such as the underarms, neck, upper chest, and groin.


Studies have suggested an inherited susceptibility to the development of skin tags. In people with Crohn's disease, skin tags around the anal opening (perianal skin tags) are common. The hormonal changes of pregnancy can also stimulate the growth of skin tags, particularly during the second trimester of pregnancy.


Skin tags are typically flesh-colored or may appear brown in light-skinned individuals. They may be smooth or wrinkled and range in size from very tiny (1 mm) to approximately the size of a grape. Although it is usually possible to recognize a stalk that attaches the skin tag to the underlying skin, very small skin tags may appear as raised bumps on the skin.


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Initially, the literature was reviewed and the considered structure was analyzed theoretically. First of all, it turned out that in a diffusive regime the difference in the optical path between the first and the last beam is of the same order as the mean optical path of beams that interfere. Knowing that it is the process of random walks, the root mean square distance from the start is equal to:


The considered structure supports 11 output channels providing unique sharp spectra. As a result, even a small deviation in the refractive index of the studied liquid significantly affects the optical spectra of the structure in corresponding spectral ranges. The list of such approaches includes many advanced computational methods that can be applied to restore the change of the refractive index from the obtained spectra. Examples include compressed sensing techniques, singular value decomposition-based methods, genetic algorithms, and others. Nevertheless, in this study, we only demonstrate the operational feasibility via the simple correlation analysis.


Another advantage of the random spectrometer is that it can operate over an extremely broad frequency range without structural modification. In current work a Gaussian profile of input optical radiation which was coupled in focusing grating coupler for C-band range [14] on a chip was used. That is why the current on-chip spectrometer works only for a fixed spectral range. In case of butt coupling the random spectrometer works in the visible and NIR wavelength range due to the use of the Silicon Nitride layer as a waveguide. The scattered light for any beam profile and irradiance will always reach the detector array, regardless of its frequency. The switch of operation frequency is done simply by changing the transfer matrix to the one calibrated for the target spectral range [13]. One more interesting realization of a sensor based on the speckle pattern processing approach was presented in [18]. Authors demonstrated a highly sensitive technique in free space for evaluating surface tension and dynamic viscosity of nanofluids. This approach can be used in combination with what is presented in the current work. NRSM not only can be used for determining surface tension and dynamic viscosity properties by mechano-optical measurements, but also for determining optical properties of analytes.


G.G., D.G. and V.K. conceived the data validation and supervised the work, V.K. developed an original idea and the concept of the experiment, A.G. fabricated the photonic integrated circuits devices, P.A. developed software for automating an experimental setup, A.K. and V.C. created hybrid nanophotonic-microfluidic design and provided an experimental study, N.G. and I.F. (Ilia Fradkin) performed the analytical and numerical calculations, I.F. (Irina Florya) provided data processing and formal analysis. All authors analyzed the data and contributed to writing the manuscript. All authors have read and agreed to the published version of the manuscript. 041b061a72


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